1729 - November 28 - Natchez Indians massacre 138 Frenchmen, 35 French women, and 56 children at Fort Rosalie, near the site of modern-day Natchez, Mississippi.

The Natchez Indians massacre of 1729 was a tragic event that occurred on November 28th at Fort Rosalie, near present-day Natchez, Mississippi. During this massacre, a group of Natchez Indians attacked the French settlement, killing 138 Frenchmen, 35 French women, and 56 children. The attack was a response to the increasing tensions between the Natchez tribe and the French colonists, who had established a presence in the region.

The massacre had significant repercussions, leading to a retaliatory campaign by the French against the Natchez tribe. This campaign culminated in the Natchez Indian War (1729-1731), during which the French, with the help of Choctaw and Chickasaw allies, eventually defeated the Natchez and effectively ended their power in the region.