1852 - March 20 – Uncle Tom's Cabin by Harriet Beecher Stowe was published in book form in Boston.

In 1852, the publication of "Uncle Tom's Cabin" marked a pivotal moment in American literature and the abolitionist movement. Written by Harriet Beecher Stowe, the novel depicted the harsh realities of slavery in the United States, focusing on the life of Uncle Tom, a long-suffering African American slave. Originally serialized in an anti-slavery newspaper, "Uncle Tom's Cabin" was published in book form on March 20 in Boston, quickly becoming a bestseller and stirring heated debates across the country.

Stowe's vivid portrayal of the cruelty and inhumanity of slavery deeply resonated with readers, both in the North and South, sparking conversations about the morality of slavery and its impact on society. The novel's impact was profound, contributing to the growing anti-slavery sentiment in the North and fueling the abolitionist cause. "Uncle Tom's Cabin" is credited with helping to raise awareness about the horrors of slavery and galvanizing support for its abolition, making it one of the most influential works of fiction in American history.